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Background
Guidelines suggest treating men with paraphilic disorder with androgen‐deprivation therapy (ADT). However, little evidence is available about the long‐term impact on bone loss and how to manage this adverse event.
Objectives
The aim of this study is to assess the impact of ADT on bone mineral density (BMD) in men treated for paraphilic disorder with the androgen receptor blocker cyproterone...
Objectives
To investigate the effect of icariin on endothelial microparticles, endothelial progenitor cells, platelets, and erectile function in spontaneously hypertensive rats.
Materials and methods
Twelve 8‐week‐old healthy male Wistar‐Kyoto rats and 12 spontaneously hypertensive rats were randomly divided into four following groups: Wistar‐Kyoto control group (normal saline 1 ml/d given by gavage),...
Background
Impaired paternal genome expression may cause poor embryonic development after in vitro fertilization (IVF).
Objective
To evaluate the expression of male infertility on embryo morphokinetics using a time‐lapse incubator and its impact on IVF cycles.
Materials and methods
This retrospective cohort study followed patients from January 2017 to August 2019. Patients were divided according...
Background
Obesity is a worldwide problem affecting the health of millions of people throughout the life course. Studies reveal that obesity impairs sperm parameters and epigenetics, potentially influencing embryonic development.
Objective
To investigate the association between preconceptional paternal body mass index (BMI) and embryo morphokinetics using a time‐lapse incubator and in vitro fertilization...
Background
The causal effects of individual risk factors of metabolic syndrome on erectile dysfunction (ED) are still unclear.
Objectives
To evaluate the causal effect of risk factors of metabolic syndrome on ED through Mendelian randomization (MR).
Materials and methods
Data for risk factors were obtained from multiple databases with 173,082–757,601 individuals, and that for ED were collected...
Background
It has been reported that the risk of erectile dysfunction (ED) is significantly higher in patients with obstructive sleep apnea (OSA), compared with patients without OSA. However, there is limited evidence on whether surgical treatments in patients with OSA could decrease ED risk.
Objectives
To assess the impact of surgical treatments for OSA on the risk of ED by analysis of claims...
Background
Although there was some evidence to suggest that the serotonergic system in the brain played an important role in premature ejaculation (PE), tryptophan hydroxylase‐2 (TPH2) is considered to be the key enzyme for the synthesis of 5‐hydroxytryptamine (5‐HT) and few studies have reported that brain TPH2 is involved in the regulation of ejaculation.
Objectives
This study aimed to investigate...
Background
Paracetamol (acetaminophen) is a frequently used nonprescription analgesic with suggested endocrine‐disrupting properties. Epidemiological evidence on the effect of paracetamol on male fecundity is sparse.
Objectives
To investigate if the use of paracetamol as an oral nonprescription mild analgesic was associated with semen quality in young men.
Materials and methods
This cross‐sectional...
Background
The connection between testicular ultrasound (US) parameters and testicular function, including both spermato‐ and steroidogenesis has been largely suggested, but their predictive properties are not routinely applied. Radiomics, a new engineering approach to radiological imaging, could overcome the visual limit of the sonographer.
Objectives
This study is aimed at extracting objective...
Background
Sperm cryopreservation has been widely used in the field of reproductive biotechnology. It applies to certain males of economic and scientific values, including livestock breeds or endangered animal species. The development of a semen extender with a low cryoprotectant concentration and an appropriate amount of trehalose and boron can prevent the deterioration of sperm parameters.
Objective...
Background
Male hypogonadism is a clinical and biochemical androgen insufficiency syndrome, becoming more prevalent with age. Exogenous testosterone is first‐choice therapy, with several side effects, including negative feedback of the hypothalamic–pituitary–gonadal axis, resulting in suppression of intratesticular testosterone production and spermatogenesis. To preserve these testicular functions...
Background
Some evidence suggests that diabetes mellitus type 1 (DM1) could affect male fertility, gonadal axis, semen parameters, and spermatogenesis because of effects of hyperglycemia and insulin deficiency. Anyhow, the exact impact of DM1 on male fertility is unclear.
Objectives
To review the studies evaluating paternity rate, male gonadal axis, and semen parameters in men with DM1.
Materials...
Background
The impact of the gut microbiome on the organism has become a growing research focus with the development of 16S rRNA sequencing. However, the effect of the gut microbiome in male reproduction has yet to be investigated.
Objective
To overview on possible mechanisms by which the gut microbiome could affect male reproduction and therapeutic opportunities related to the gut microbiome
...
Background
Due to the highly variable clinical phenotype, Klinefelter Syndrome is underdiagnosed.
Objective
Assessment of supervised machine learning based prediction models for identification of Klinefelter Syndrome among azoospermic patients, and comparison to expert clinical evaluation.
Materials and methods
Retrospective patient data (karyotype, age, height, weight, testis volume, follicle‐stimulating...
Background
Establishing an efficient, simple and inexpensive method for freezing ram epididymal sperm so that the quality and fertility of spermatozoa could be maintained for a longer period after thawing is of great practical value.
Objectives
To optimize freezing and thawing protocol for ram epididymal sperm using either ethylene glycol (EG) or glycerol (GLY) as cryoprotectants (CPAs). Then,...
Background
Chronic pain and opioid treatment are associated with increased risk of male hypogonadism and subsequently decreased muscle function. A diagnosis of hypogonadism is based on the presence of low total testosterone and associated symptoms. The effect of testosterone replacement therapy on muscle function in men with chronic pain and low total testosterone remains to be investigated.
Objectives...
Background
Exposure to environmental pollution via different mechanisms is associated with multiple endocrine dysfunctions. Organophosphate esters (OPEs) are endocrine‐disrupting chemicals that affect sex steroid hormones.
Purpose
We aimed to study the effect of OPEs and their metabolites, such as diphenyl phosphate (DPHP), bis(1,3‐dichloro‐2‐propyl) phosphate (BDCPP), bis(2‐chloroethyl) phosphate...
Background
In the literature, there is not sufficient data on factors affecting the development of complications in patients with penile fracture after early surgical intervention.
Objectives
To investigate the predictors of long‐term complications in patients who underwent immediate surgical repair for penile fracture.
Materials/methods
This clinical study included a total of 31 cases of penile...
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